Gee this is the first I've heard of this problem and I'll need to investigate. On the surface, I don't see why Vine Type would not work in integrated pipeline mode -- it uses HttpContext extensively but not in Application_Start. Vine Type uses no HttpHandlers (that I can think of off the top of my head) and is extremely server centric -- basically all processing occurs in the PageLoad() function. I've been testing Vine Type on my IIS7 on Vista64 at home but perhaps "classic" is the default and so I haven't seen any problems. I'll look into this.
On a side note I found it amusing that folks are looking for support of the latest feature of the most recent IIS while others report that GoDaddy still needs coaxing to support .NET 2.0. :)
vine type - content management with standards in mind - vinetype.com